| Steady state urinary excretion of theophylline and its metabolites in the presence of erythromycin. | |
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MedLine Citation:
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PMID: 7071419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of erythromycin on the quantitative pattern of urinary excretion of theophylline and its known metabolites at steady state in eight human subjects was examined. The percent of dose excreted of the various compounds in the absence and presence of the antibiotic were as follows: theophylline, 9.3% vs. 16.3%; 1, 3-dimethyluric acid, 51.9% vs. 59.6%; 3-methylxanthine, 11.9% vs. 13.0%; and 1-methyluric acid, 27.3% vs. 31.6%. These results show that erythromycin did not influence the metabolism of theophylline under the experimental protocol employed. |
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Authors:
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S Melethil; A Dutta; P B Ryan; S K Pingleton; S J Kelly |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 35 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1982 Feb |
Date Detail:
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Created Date: 1982-06-14 Completed Date: 1982-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 341-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aminophylline / metabolism Biotransformation Chromatography, High Pressure Liquid Drug Interactions Erythromycin / pharmacology* Humans Male Theophylline / urine* |
| Chemical | |
Reg. No./Substance:
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114-07-8/Erythromycin; 317-34-0/Aminophylline; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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