| Steady-state diffusion imaging for MR in-vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3 tesla--preliminary results. | |
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MedLine Citation:
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PMID: 17977685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To demonstrate the feasibility of time-reversed fast imaging with steady-state precession (FISP) called PSIF for diffusion-weighted imaging of cartilage and cartilage transplants in a clinical study. MATERIAL AND METHODS: In a cross-sectional study 15 patients underwent MRI using a 3D partially balanced steady-state gradient echo pulse sequence with and without diffusion weighting at two different time points after matrix-associated autologous cartilage transplantation (MACT). Mean diffusion quotients (signal intensity without diffusion-weighting divided by signal intensity with diffusion weighting) within the cartilage transplants were compared to diffusion quotients found in normal cartilage. RESULTS: The global diffusion quotient found in repair cartilage was significantly higher than diffusion values in normal cartilage (p<0.05). There was a decrease between the earlier and the later time point after surgery. CONCLUSIONS: In-vivo diffusion-weighted imaging based on the PSIF technique is possible. Our preliminary results show follow-up of cartilage transplant maturation in patients may provide additional information to morphological assessment. |
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Authors:
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Tallal Charles Mamisch; Marion Irene Menzel; Goetz Hannes Welsch; Bernd Bittersohl; Erich Salomonowitz; Pavol Szomolanyi; Jens Kordelle; Stefan Marlovits; Siegfried Trattnig |
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Publication Detail:
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Type: Journal Article Date: 2007-10-30 |
Journal Detail:
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Title: European journal of radiology Volume: 65 ISSN: 0720-048X ISO Abbreviation: Eur J Radiol Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-08 Completed Date: 2008-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 72-9 Citation Subset: IM |
Affiliation:
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Department of Orthopaedic Surgery, University of Berne, Inselspital, CH-3010 Berne, Switzerland. mamisch@bwh.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Cartilage, Articular / metabolism*, pathology* Cell Transplantation / methods Chondrocytes / transplantation* Cross-Sectional Studies Diffusion Magnetic Resonance Imaging / methods* Female Follow-Up Studies Humans Imaging, Three-Dimensional Knee Joint / surgery* Male Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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