| Staurosporine-induced apoptosis in P388D1 macrophages involves both extrinsic and intrinsic pathways. | |
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MedLine Citation:
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PMID: 19524691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of P388D1, a macrophage-like cell line, with staurosporine triggered apoptosis through the activation of caspase-9 and caspase-3. Unexpected effects of staurosporine on the induction of apoptosis were the activation of caspase-8, and an increase of the levels of TNF-alpha. The increased TNF-alpha levels led to activation of caspase-8 by an autocrine effect via the TNF receptor expressed by the P388D1 macrophages. In contrast, P388D1 macrophages that either had been exposed to UV light or treated with dexamethasone did not undergo apoptosis. |
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Authors:
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Yuko Nakamura-López; Rosa Elena Sarmiento-Silva; Julio Moran-Andrade; Beatriz Gómez-García |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-12 |
Journal Detail:
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Title: Cell biology international Volume: 33 ISSN: 1095-8355 ISO Abbreviation: Cell Biol. Int. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1026-31 Citation Subset: IM |
Affiliation:
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Laboratory of Virology, Department of Microbiology and Parasitology, Universidad Nacional Autónoma de México,Ciudad Universitaria, México DF 04510, Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents, Hormonal / pharmacology Apoptosis* Caspase 3 / drug effects, metabolism Caspase 8 / drug effects, metabolism Caspase 9 / drug effects, metabolism Cell Line, Tumor Cell Survival / drug effects, physiology DNA Fragmentation / drug effects Dexamethasone / pharmacology Macrophages / drug effects*, radiation effects Mice Protein Kinase Inhibitors / pharmacology* Receptors, Tumor Necrosis Factor, Type I / agonists, metabolism Signal Transduction / drug effects, physiology Staurosporine / pharmacology* Tumor Necrosis Factor-alpha / biosynthesis, drug effects Ultraviolet Rays / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Hormonal; 0/Protein Kinase Inhibitors; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Tumor Necrosis Factor-alpha; 50-02-2/Dexamethasone; 62996-74-1/Staurosporine; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Caspase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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