| Status of the thymectomy trial for nonthymomatous myasthenia gravis patients receiving prednisone. | |
| | |
MedLine Citation:
|
PMID: 18567886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The primary study [MGTX] aims to answer three questions: does extended transsternal thymectomy combined with the prednisone protocol, when compared with the prednisone protocol alone: (1) result in a greater improvement in myasthenic weakness, (2) result in a lower total dose of prednisone, thus decreasing the likelihood of concurrent and long-term toxic effects, (3) enhance the quality of life by reducing adverse events and symptoms associated with the therapies? Inclusion criteria are MGFA Class 2, 3, or 4; acetylcholine receptor antibody positive; age at least 18.0 years and <60.0 years; MG history of <3 years. Patients can be prednisone naïve or not. The National Institute for Neurological Disorders and Stroke awarded funding for MGTX in September 2005, and NIH awarded funding for the ancillary Biomarkers study (BioMG) in February 2006. Diverse regulatory obstacles have been encountered in this international study, but we now have a total of over 70 centers in 22 countries (North America, South America, Europe, Australasia, South Africa) either actively recruiting or at various levels of readiness. |
| | |
Authors:
|
John Newsom-Davis; Gary Cutter; Gil I Wolfe; Henry J Kaminski; Alfred Jaretzki; Greg Minisman; Inmaculada Aban; Robin Conwit |
Related Documents
:
|
21273226 - Nature-assisted therapy : systematic review of controlled and observational studies. 22433246 - Influence of dependent personality status on the outcome and health service costs of he... 22874896 - Thoron and radon measurements in romanian schools. 9541066 - Perceptions and priorities in disease eradication: dracunculiasis eradication in africa. 9285276 - Equity and distributive justice in european health care reform. 1832786 - Benefits of sport and physical activity for the disabled: implications for the individu... |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
|
Title: Annals of the New York Academy of Sciences Volume: 1132 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-06-23 Completed Date: 2008-09-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 344-7 Citation Subset: IM |
Affiliation:
|
University of Oxford, Oxford, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Humans Middle Aged Myasthenia Gravis / drug therapy*, pathology, surgery* Prednisone / therapeutic use* Thymectomy* Time Factors |
| Chemical | |
Reg. No./Substance:
|
53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Extended transcervical thymectomy in the treatment of myasthenia gravis.
Next Document: List of abstracts.