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Status report from 'double agent HLA': Health and disease.
MedLine Citation:
PMID:  23046976     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The human major histocompatibility complex is a multi-gene ∼4Mb of DNA including the highly polymorphic HLA genes which are fundamental in effecting a healthy immune response. Detailed knowledge of the structure and function of HLA genes and their alleles and HLA proteins and their allotypes has rapidly evolved because of their role in clinical transplantation. A significant additional finding is the association or linkage of a wide range of diseases with HLA. We review the function of HLA and the history of disease association studies and focus on specific informative examples in the context of recent genome-wide screening analyses.
Authors:
Philip Dyer; Roger McGilvray; Victoria Robertson; David Turner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-6
Journal Detail:
Title:  Molecular immunology     Volume:  -     ISSN:  1872-9142     ISO Abbreviation:  Mol. Immunol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905289     Medline TA:  Mol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Histocompatibility & Immunogenetics Laboratory, Scottish National Blood Transfusion Service, Royal Infirmary of Edinburgh, Scotland, United Kingdom. Electronic address: phil.dyer@nhs.net.
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