Document Detail


Status epilepticus following intentional overdose of fluvoxamine: a case report with serum fluvoxamine concentration.
MedLine Citation:
PMID:  17952747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that is used in the management of depression and obsessive compulsive disorders. We report a patient with status epilepticus requiring quadruple anti-convulsant treatment following a fluvoxamine overdose. CASE REPORT: A 25-year-old female presented with drowsiness at 12 hours following deliberate ingestion of 9.6 grams of fluvoxamine. Sixteen hours after ingestion, she developed status epilepticus that required treatment with benzodiazepines (lorazepam and midazolam), thiopentone, phenytoin and phenobarbitone. Her serum fluvoxamine concentration on presentation was 1970 microg/L (therapeutic 160-220 microg/L) and routine toxicological screening was negative for other drugs. She was discharged home after 72 hours with no further episodes of seizures. DISCUSSION: Most patients with fluvoxamine poisoning are either asymptomatic or may develop mild signs of serotonergic toxicity. Although serotonin syndrome and isolated seizures are reported in fluvoxamine poisoning, we report the first patient with confirmed isolated fluvoxamine toxicity who developed status epilepticus.
Authors:
David M Wood; Yadhunanthanan Rajalingam; Shaun L Greene; Phillip E Morgan; David Gerrie; Alison L Jones; Paul I Dargan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical toxicology (Philadelphia, Pa.)     Volume:  45     ISSN:  1556-3650     ISO Abbreviation:  Clin Toxicol (Phila)     Publication Date:    2007 Oct-Nov
Date Detail:
Created Date:  2007-12-13     Completed Date:  2008-01-03     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101241654     Medline TA:  Clin Toxicol (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  791     Citation Subset:  AIM; IM    
Affiliation:
Guy's and St. Thomas' Poisons Unit, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. David.Wood@gstt.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Antidepressive Agents, Second-Generation / blood,  poisoning*
Barbiturates / therapeutic use
Benzodiazepines / therapeutic use
Drug Therapy, Combination
Female
Fluvoxamine / blood,  poisoning*
Humans
Overdose
Poisoning / drug therapy,  etiology*,  physiopathology
Seizures / chemically induced,  physiopathology
Status Epilepticus / chemically induced*,  physiopathology
Suicide, Attempted*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Barbiturates; 12794-10-4/Benzodiazepines; 54739-18-3/Fluvoxamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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