| Status of the "East Side hypothesis" (transovarial interference) 25 years later. | |
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MedLine Citation:
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PMID: 19538274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rocky Mountain spotted fever (RMSF) cases in the notorious Bitterroot Valley outbreak of the early 20th century were peculiarly distributed, with virtually all reported from the west side of the valley. Such a distribution remained unexplained until Burgdorfer and colleagues (1981) reported that endosymbiotic rickettsiae were prevalent in wood ticks on the east side of the Bitterroot River valley but not on the west side. The "East Side agent" was said to prevent the transovarial transmission of Rickettsia rickettsii, thereby severely limiting the prevalence of the latter. This hypothesis has been considered one of the most innovative explanations for an epidemiological conundrum and, indeed, has generally been accepted as a fact in the medical entomology literature. I review the evidence for the interference hypothesis, and suggest that the distribution of the Bitterroot Valley RMSF outbreak might actually have its basis in habitat or microclimate-related factors, as opposed to reflecting interspecific competition by closely related rickettsiae. |
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Authors:
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Sam R Telford |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1166 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 144-50 Citation Subset: IM |
Affiliation:
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Division of Infectious Diseases, Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, Massachusetts 01536, USA. sam.telford@tufts.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Geography Humans Montana Rickettsia rickettsii / pathogenicity* Rocky Mountain Spotted Fever* / epidemiology, microbiology, transmission Ticks / microbiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI 064218/AI/NIAID NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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