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Status dystonicus: Predictors of outcome and progression patterns of underlying disease.
MedLine Citation:
PMID:  22488948     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Status dystonicus (SD) is a rare, life-threatening disorder characterized by acute worsening of generalized dystonia. METHODS: This study was conducted to characterize the pathogenesis, clinical course, and prognosis of SD. We reviewed the records of six centers and analyzed them together with all the cases previously reported in the literature. RESULTS: Eighty-nine episodes occurring in 68 patients were studied. The majority of patients were males (64.7%), were <15 years of age (58.8%), and had secondary dystonia as the underlying condition (37.8%). The episodes were mainly characterized by tonic muscle spasms (68.5%), with phasic forms more common in secondary forms and among females. Almost all cases needed a multistaged approach, with surgery being the most successful strategy. Neurological conditions preceding the episode worsened in 16.2% of cases (ending in death in 10.3%). CONCLUSIONS: The course and outcome of SD is highly variable; male gender and prevalent tonic phenotype predict a poor outcome © 2012 Movement Disorder Society.
Authors:
Alfonso Fasano; Lucia Ricciardi; Anna Rita Bentivoglio; Carlotta Canavese; Giovanna Zorzi; Igor Petrovic; Nikola Kresojevic; Vladimir S Kostić; Marina Svetel; Norbert Kovacs; Istvan Balas; Agathe Roubertie; Devendra Mishra; Paolo Mariotti; Teresa Temudo; Nardo Nardocci
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-6
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  -     ISSN:  1531-8257     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Movement Disorder Society.
Affiliation:
Istituto di Neurologia, Università Cattolica del Sacro Cuore, Rome, Italy; AFaR-Fatebenefratelli Association for Biomedical Research, Neuromed Institute, Rome, Italy. alfonso.fasano@rm.unicatt.it.
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