Document Detail


Statistically significant differences in the number of CD24 positive muscle fibers and satellite cells between sarcoglycanopathy and age-matched Becker muscular dystrophy patients.
MedLine Citation:
PMID:  10397078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: The aim of this study was to reveal variations in the patterns of expression of the cell surface proteins in regenerating fibers and those in the number of satellite cells to gain an understanding of the pathological processes involved in sarcoglycanopathy. METHODS: We have reported that there is a reduction of the beta-1 subunit of laminin, heparan sulfate proteoglycan (HSPG), and HCAM (CD44) in Japanese patients with sarcoglycanopathy. Here, we investigated immunohistochemically the expression of the neural cell adhesion molecule (NCAM), which is a marker for human regenerating muscle and satellite cell, and CD24, which appears to be expressed in the early stages of the regeneration process. PATIENTS: We investigated six Japanese patients with sarcoglycanopathy, and compared to age-matched Becker muscular dystrophy. RESULTS: We found that the incidences of muscle fibers with increased NCAM were not statistically different between the two groups. However, the incidences of muscle fibers with increased CD24 and those of NCAM positive satellite cells were very low in sarcoglycanopathy and were statistically different between sarcoglycanopathy and age-matched Becker muscular dystrophies. CONCLUSION: The poor expression of CD24 and the fewer satellite cells in sarcoglycanopathy without significant difference in the number of total regenerating fibers suggest that a different regeneration process is involved in sarcoglycanopathy compared to that in other types of muscular dystrophy.
Authors:
I Higuchi; H Kawai; M Kawajiri; H Fukunaga; T Horikiri; T Niiyama; M Nakagawa; K Arimura; M Osame
Related Documents :
10662648 - Bmp signaling is essential for development of skeletogenic and neurogenic cranial neura...
2438288 - Biochemical and functional characterization of a novel neuron-glia adhesion molecule th...
7815468 - Vase exon expression alters ncam-mediated cell-cell interactions.
3511068 - Nerve growth factor enhances expression of neuron-glia cell adhesion molecule in pc12 c...
7933988 - Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo.
23596088 - Inhibition of fibroblast adhesion by covalently immobilized protein repellent polymer c...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  38     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-09     Completed Date:  1999-08-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  412-5     Citation Subset:  IM    
Affiliation:
The Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age of Onset
Antigens, CD / metabolism*
Antigens, CD24
Cytoskeletal Proteins / deficiency*
Female
Humans
Immunoenzyme Techniques
Male
Membrane Glycoproteins / deficiency*
Middle Aged
Muscle Fibers, Skeletal / metabolism*,  pathology
Muscle, Smooth / metabolism*
Muscular Dystrophies / metabolism*,  pathology
Neural Cell Adhesion Molecules / metabolism
Sarcoglycans
Sarcolemma / metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD24; 0/CD24 protein, human; 0/Cytoskeletal Proteins; 0/Membrane Glycoproteins; 0/Neural Cell Adhesion Molecules; 0/Sarcoglycans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analysis of the CAG repeat number in a patient with Huntington's disease.
Next Document:  Phlebosclerosis of the colon with positive anti-centromere antibody.