Document Detail

Statistical voxel-wise analysis of ictal SPECT reveals pattern of abnormal perfusion in patients with temporal lobe epilepsy.
MedLine Citation:
PMID:  16400416     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the pattern of perfusion abnormalities in ictal and interictal brain perfusion SPECT images (BSI) from patients with temporal lobe epilepsy (TLE). METHOD: It was acquired interictal and ictal BSI from 24 patients with refractory TLE. BSIs were analyzed by visual inspection and statistical parametric mapping (SPM2). Statistical analysis compared the patients group to a control group of 50 volunteers. The images from patients with left-TLE were left-right flipped. RESULTS: It was not observed significant perfusional differences in interictal scans with SPM. Ictal BSI in SPM analysis revealed hyperperfusion within ipsilateral temporal lobe (epileptogenic focus) and also contralateral parieto-occipital region, ipsilateral posterior cingulate gyrus, occipital lobes and ipsilateral basal ganglia. Ictal BSI also showed areas of hypoperfusion. CONCLUSION: In a group analysis of ictal BSI of patients with TLE, voxel-wise analysis detects a network of distant regions of perfusional alteration which may play active role in seizure genesis and propagation.
Bárbara Juarez Amorim; Elba Cristina Sá de Camargo Etchebehere; Edwaldo Eduardo Camargo; Pablo Augusto Rio; Leonardo Bonilha; Chris Rorden; Li Min Li; Fernando Cendes
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Publication Detail:
Type:  Journal Article     Date:  2005-12-15
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  63     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-09     Completed Date:  2006-06-01     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  977-83     Citation Subset:  IM    
Department of Radiology, Faculdade de Ciências Médicas, UNICAMP, Campinas, Brazil.
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MeSH Terms
Brain / blood supply*,  radionuclide imaging
Case-Control Studies
Cerebrovascular Circulation / physiology
Child, Preschool
Chronic Disease
Data Interpretation, Statistical
Epilepsy, Temporal Lobe / radionuclide imaging*
Middle Aged
Tomography, Emission-Computed, Single-Photon

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