| Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain. | |
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MedLine Citation:
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PMID: 21934696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tc-99m ethyl cysteinate diethylester (ECD) and Tc-99m hexamethyl propylene amine oxime (HMPAO) are commonly used for single-photon emission computed tomography (SPECT) studies of a variety of neurologic disorders. Although these tracers have been very helpful in diagnosing and guiding treatment of neurologic disease, data describing the distribution and laterality of these tracers in normal resting brain are limited. Advances in quantitative functional imaging have demonstrated the value of using resting studies from control populations as a baseline to account for physiologic fluctuations in cerebral perfusion. Here, we report results from 30 resting Tc-99m ECD SPECT scans and 14 resting Tc-99m HMPAO scans of normal volunteers with no history of neurologic disease. Scans were analyzed with regions of interest and with statistical parametric mapping, with comparisons performed laterally (left vs. right), as well as for age, gender, and handedness. The results show regions of significant asymmetry in the normal controls affecting widespread areas in the cerebral hemispheres, but most marked in superior parietotemporal region and frontal lobes. The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease. |
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Authors:
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Benjamin H Brinkmann; David T Jones; Matt Stead; Noojan Kazemi; Terence J O'Brien; Elson L So; Hal Blumenfeld; Brian P Mullan; Gregory A Worrell |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-09-21 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 32 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-03 Completed Date: 2012-02-28 Revised Date: 2012-04-11 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 190-8 Citation Subset: IM |
Affiliation:
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Mayo Systems Electrophysiology Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain / metabolism, radionuclide imaging* Brain Mapping / instrumentation, methods, statistics & numerical data* Cysteine / analogs & derivatives*, diagnostic use, pharmacokinetics Data Interpretation, Statistical Dominance, Cerebral Female Humans Image Processing, Computer-Assisted Male Organotechnetium Compounds / diagnostic use, pharmacokinetics* Radiopharmaceuticals / diagnostic use, pharmacokinetics* Technetium Tc 99m Exametazime / diagnostic use, pharmacokinetics* Tomography, Emission-Computed, Single-Photon / instrumentation, methods, statistics & numerical data* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01-NS63039/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m bicisate; 100504-35-6/Technetium Tc 99m Exametazime; 52-90-4/Cysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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