Document Detail

Statistical methodology for clinical trials of caries prophylactic agents--current knowledge.
MedLine Citation:
PMID:  6597135     Owner:  NLM     Status:  MEDLINE    
Statistical methodology underlying clinical trials of caries prophylactic agents published up to 1982 is summarized. The various caries indices used to express an individual's caries increment over a period of time are considered, along with some standard models used to describe caries incremental and prevalence data. The parametric statistical techniques generally employed to test for significant differences between the caries preventive agents under investigation are robust for the departures from normality found in caries data with the large sample sizes involved. Methods of estimating sample sizes are considered along with the various multiple comparison tests suitable for analysing multi-group trials. The advantages of using either an analysis of covariance or stratification procedures in certain situations are discussed, along with suitable covariables which have been put forward. Ways of improving the efficiency of clinical trials by selecting subjects are also considered. Models put forward to describe diagnostic errors are examined. However, it is generally found that examiner error in long term trials is small. The use of sequential tests in clinical trials needs further development.
H Worthington
Related Documents :
20558225 - Practical approaches to dose selection for first-in-human clinical trials with novel bi...
3398745 - Is there a role for surgery in the acute management of infective endocarditis? a decisi...
19924525 - Adherence and its measurement in phase 2/3 microbicide trials.
11746315 - Combining components of quality of life to increase precision and evaluate trade-offs.
15742725 - Quaternion-based strap-down integration method for applications of inertial sensing to ...
19700605 - Effects of methyl mercury in combination with polychlorinated biphenyls and brominated ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International dental journal     Volume:  34     ISSN:  0020-6539     ISO Abbreviation:  Int Dent J     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-04-04     Completed Date:  1985-04-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374714     Medline TA:  Int Dent J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  278-84     Citation Subset:  D; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Cariostatic Agents / administration & dosage,  therapeutic use*
Clinical Trials as Topic*
DMF Index
Dental Caries / epidemiology,  physiopathology,  prevention & control
Models, Theoretical
Research Design
Sampling Studies
Statistics as Topic*
Reg. No./Substance:
0/Cariostatic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oral health status and tradition in Australia.
Next Document:  Use of the CPITN in populations under 20 years of age.