Document Detail


Statistical methodology for clinical trials of caries prophylactic agents--current knowledge.
MedLine Citation:
PMID:  6597135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Statistical methodology underlying clinical trials of caries prophylactic agents published up to 1982 is summarized. The various caries indices used to express an individual's caries increment over a period of time are considered, along with some standard models used to describe caries incremental and prevalence data. The parametric statistical techniques generally employed to test for significant differences between the caries preventive agents under investigation are robust for the departures from normality found in caries data with the large sample sizes involved. Methods of estimating sample sizes are considered along with the various multiple comparison tests suitable for analysing multi-group trials. The advantages of using either an analysis of covariance or stratification procedures in certain situations are discussed, along with suitable covariables which have been put forward. Ways of improving the efficiency of clinical trials by selecting subjects are also considered. Models put forward to describe diagnostic errors are examined. However, it is generally found that examiner error in long term trials is small. The use of sequential tests in clinical trials needs further development.
Authors:
H Worthington
Related Documents :
3398745 - Is there a role for surgery in the acute management of infective endocarditis? a decisi...
16422035 - Management of data used in clinical trials which is unevenly distributed at baseline.
3902345 - Increasing the sensitivity of caries clinical trials by applying logistic modelling to ...
15606425 - Evaluation of community-intervention trials via generalized linear mixed models.
10179545 - Computer-based patient records and mathematical processing: brain-unicard system experi...
3398745 - Is there a role for surgery in the acute management of infective endocarditis? a decisi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International dental journal     Volume:  34     ISSN:  0020-6539     ISO Abbreviation:  Int Dent J     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-04-04     Completed Date:  1985-04-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374714     Medline TA:  Int Dent J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  278-84     Citation Subset:  D; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Cariostatic Agents / administration & dosage,  therapeutic use*
Child
Clinical Trials as Topic*
DMF Index
Dental Caries / epidemiology,  physiopathology,  prevention & control
Humans
Models, Theoretical
Probability
Research Design
Sampling Studies
Statistics as Topic*
Chemical
Reg. No./Substance:
0/Cariostatic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Oral health status and tradition in Australia.
Next Document:  Use of the CPITN in populations under 20 years of age.