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Statistical issues in carcinogenic risk assessment.
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MedLine Citation:
PMID:  2050065     Owner:  NLM     Status:  MEDLINE    
Considerable progress has been made on the development of a variety of analytical methods to aid in the carcinogenic risk associated with exposure to both occupational and environmental agents. Although the development of these methods has been accompanied by consideration of many statistical issues, there are many areas where additional effort could be directed if these analytical methods are to provide the most appropriate interpretation of risk. These issues include methods of combining multiple studies to obtain an overall risk estimate, the robustness of the statistical model, methods of selection among competing models, an assessment of the effect of different measures of exposure on the estimated dose-response relationship, and development of surveillance methodology. These issues are discussed, and productive areas of future research are indicated.
H E Rockette
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental health perspectives     Volume:  90     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-07-25     Completed Date:  1991-07-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  IM    
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261.
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MeSH Terms
Carcinogens, Environmental*
Data Interpretation, Statistical
Mass Screening
Models, Statistical*
Neoplasms / chemically induced*,  diagnosis
Reg. No./Substance:
0/Carcinogens, Environmental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 1 Year: 1991
Volume: 90First Page: 223 Last Page: 227
ID: 1519477
PubMed Id: 2050065

Statistical issues in carcinogenic risk assessment.
H E Rockette
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261.

Article Categories:
  • Research Article

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