| Statistical decisions and the interim analyses of clinical trials. | |
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MedLine Citation:
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PMID: 21222041 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This paper analyzes statistical decisions during the interim analyses of clinical trials. After some general remarks about the ethical and scientific demands of clinical trials, I introduce the notion of a hard-case clinical trial, explain the basic idea behind it, and provide a real example involving the interim analyses of zidovudine in asymptomatic HIV-infected patients. The example leads me to propose a decision analytic framework for handling ethical conflicts that might arise during the monitoring of hard-case clinical trials. I use computer simulations to show how the framework can assist in reconciling certain ethical conflicts. The framework is partial, lacking the precision of a complete systematization of statistical monitoring procedures in practice. |
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Authors:
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Roger Stanev |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Theoretical medicine and bioethics Volume: 32 ISSN: 1573-0980 ISO Abbreviation: Theor Med Bioeth Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9805378 Medline TA: Theor Med Bioeth Country: Netherlands |
Other Details:
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Languages: eng Pagination: 61-74 Citation Subset: E; IM |
Affiliation:
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Department of Philosophy, University of British Columbia, 1866 Main Mall E370, Vancouver, BC, V6T 1Z1, Canada, rstanev@interchange.ubc.ca. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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