| Statistical considerations in infant nutrition trials. | |
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MedLine Citation:
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PMID: 10102245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infant nutrition trials usually require developmental follow-up, often to 18 mon, and sometimes beyond reading ability at age 7 yr. They are therefore logistically complex and costly, and should be conducted to a high statistical standard. With examples, we focus on: good practice in nutrition trials and the goal of a common protocol; how to set plausible trial targets and to work out trial size accordingly; statistical observations on assessing visual maturation; and methods of randomization, including the method known as minimization, which can be adapted to select more appropriately a comparison cohort of breast-fed infants. We end with discussion of analysis and reporting standards, including the give-aways (or tell-tale signs) to be on the look out for. A Cochrane Collaboration for systematic review of randomized trials of infant nutrition is proposed. |
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Authors:
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S M Gore |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Lipids Volume: 34 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-06-10 Completed Date: 1999-06-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 185-97 Citation Subset: IM |
Affiliation:
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MRC Biostatistics Unit, Cambridge, United Kingdom. sheila.gore@mrc-bsu.cam.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Clinical Trials as Topic* Cohort Studies Data Interpretation, Statistical* Follow-Up Studies Humans Infant Infant Nutritional Physiological Phenomena* Multicenter Studies as Topic Research Design Vision, Ocular |
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