Document Detail

Statistical considerations in infant nutrition trials.
MedLine Citation:
PMID:  10102245     Owner:  NLM     Status:  MEDLINE    
Infant nutrition trials usually require developmental follow-up, often to 18 mon, and sometimes beyond reading ability at age 7 yr. They are therefore logistically complex and costly, and should be conducted to a high statistical standard. With examples, we focus on: good practice in nutrition trials and the goal of a common protocol; how to set plausible trial targets and to work out trial size accordingly; statistical observations on assessing visual maturation; and methods of randomization, including the method known as minimization, which can be adapted to select more appropriately a comparison cohort of breast-fed infants. We end with discussion of analysis and reporting standards, including the give-aways (or tell-tale signs) to be on the look out for. A Cochrane Collaboration for systematic review of randomized trials of infant nutrition is proposed.
S M Gore
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lipids     Volume:  34     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-97     Citation Subset:  IM    
MRC Biostatistics Unit, Cambridge, United Kingdom.
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MeSH Terms
Child, Preschool
Clinical Trials as Topic*
Cohort Studies
Data Interpretation, Statistical*
Follow-Up Studies
Infant Nutritional Physiological Phenomena*
Multicenter Studies as Topic
Research Design
Vision, Ocular

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