Document Detail

Statistical approaches to evaluating the effect of risk factors on the pain of knee osteoarthritis in longitudinal studies.
MedLine Citation:
PMID:  19584728     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: We describe commonly used measures of knee pain in longitudinal studies and review various analytic approaches to evaluating the effect of a risk factor on each type of pain measure.
RECENT FINDINGS: In longitudinal epidemiologic studies of knee pain, frequent knee pain and activity-related pain severity are the most commonly used measures for pain. Various analytic approaches have been used to evaluate the effect of a risk factor on each type of pain measure. Analytic approaches utilized include the generalized estimating equations model and the mixed-effects linear regression model for pain severity assessed as a continuous outcome variable, the mixed-effects logistic regression model and conditional logistic regression model for pain exacerbation measured as a dichotomous outcome variable, and a mixed-effects regression model, stratified proportional odds model, and a multistate transition model for pain severity measured as an ordinal outcome variable.
SUMMARY: Compared with cross-sectional studies, longitudinal studies allow investigators to assess the effect of change in a risk factor of interest on change in risk of knee pain or change in pain severity. With appropriate analysis methods, investigators are able to minimize potential confounders that differ among individuals or knees but which do not vary over time within a person or knee.
Yuqing Zhang; Bin Zhang; Barton Wise; Jingbo Niu; Yanyan Zhu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  21     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-11-04     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  513-9     Citation Subset:  IM    
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MeSH Terms
Longitudinal Studies
Mental Status Schedule
Models, Statistical
Osteoarthritis, Knee / complications,  physiopathology*,  psychology
Pain / etiology,  physiopathology*,  psychology
Pain Measurement
Risk Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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