| Statistical analysis of pharmacokinetic models in dynamic contrast-enhanced magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 16686044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper assesses the estimation of kinetic parameters from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Asymptotic results from likelihood-based nonlinear regression are compared with results derived from the posterior distribution using Bayesian estimation, along with the output from an established software package (MRIW). By using the estimated error from kinetic parameters, it is possible to produce more accurate clinical statistics, such as tumor size, for patients with breast tumors. Further analysis has also shown that Bayesian methods are more accurate and do not suffer from convergence problems, but at a higher computational cost. |
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Authors:
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Volker J Schmid; Brandon J Whitcher; Guang-Zhong Yang; N Jane Taylor; Anwar R Padhani |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention Volume: 8 ISSN: - ISO Abbreviation: Med Image Comput Comput Assist Interv Publication Date: 2005 |
Date Detail:
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Created Date: 2006-05-11 Completed Date: 2006-06-06 Revised Date: 2010-04-12 |
Medline Journal Info:
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Nlm Unique ID: 101249582 Medline TA: Med Image Comput Comput Assist Interv Country: Germany |
Other Details:
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Languages: eng Pagination: 886-93 Citation Subset: IM |
Affiliation:
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Institute for Biomedical Engineering, Suite 5, Sherfield Building, Imperial College, South Kensington, London SW7 2AZ, United Kingdom. v.schmid@imperial.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast Neoplasms
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diagnosis*,
metabolism* Computer Simulation Contrast Media / pharmacokinetics Data Interpretation, Statistical Gadolinium DTPA / diagnostic use*, pharmacokinetics* Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Models, Biological* Models, Statistical Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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