Statistical analysis of histomorphological findings in medullary thyroid carcinoma: distinction between the different familial forms of the disease. G.E.T.C. Groupe d'Etude des Tumeurs a Calcitonine.

Statistical analysis of histomorphological findings in medullary thyroid carcinoma: distinction between the different familial forms of the disease. G.E.T.C. Groupe d'Etude des Tumeurs a Calcitonine.

MedLine Citation:	PMID: 1362419 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	A multifactorial analysis of morphological findings was performed on 153 cases of medullary thyroid carcinoma (MTC). The aim of the study was to utilize histological criteria to discriminate between MTC associated with multiple endocrine neoplasia type 2A (MEN 2A) and that associated with the inherited MTC only syndrome. The presence of fusiform cells associated with several other markers seemed to be more predictive of MEN 2A. A comparison of inherited MTC only and sporadic MTC only showed fusiform cells to be significantly less common in inherited MTC only. These results suggest that the inherited MTC only syndrome is a distinct clinical and morphological entity. Further investigations are needed to confirm the findings and understand its implications.

Authors:	B Franc; M Rosenberg-Bourgin; B Auvert; B Caillou; N Dutrieux-Berger; J Floquet; M Houcke-Lecomte; E Justrabo; F Labat-Moleur; M F Le Bodic
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Publication Detail:	Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Detail:	Title: Henry Ford Hospital medical journal Volume: 40 ISSN: 0018-0416 ISO Abbreviation: Henry Ford Hosp. Med. J. Publication Date: 1992
Date Detail:	Created Date: 1993-02-17 Completed Date: 1993-02-17 Revised Date: 2006-11-15
Medline Journal Info:	Nlm Unique ID: 0122304 Medline TA: Henry Ford Hosp Med J Country: UNITED STATES
Other Details:	Languages: eng Pagination: 261-3 Citation Subset: IM
Affiliation:	Department of Pathology, Faculte Paris Ouest, France.
Export Citation:	APA/MLA Format Download EndNote Download BibTex
MeSH Terms
Descriptor/Qualifier:	Carcinoma / complications, genetics, pathology Female Humans Male Multiple Endocrine Neoplasia / complications Thyroid Neoplasms / complications, genetics, pathology

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