| Statins and vein graft failure in coronary bypass surgery. | |
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MedLine Citation:
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PMID: 22326889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Saphenous vein grafts used in coronary artery bypass graft surgery suffer from lower patency rates compared to left internal mammary artery. A number of clinical trials and observational studies have demonstrated a significant benefit of statin treatment on vein graft patency. Aside from their well-known lipid-lowering capacities, statins exert pleiotropic effects by direct inhibition of the mevalonate pathway in the wall of these grafts. This leads to reduced geranylgeranylation of small GTPases such as Rho and Rac. Through this LDL-independent mechanism, statins improve endothelial function and reduce vascular inflammation and oxidative stress, inhibiting also smooth muscle cell proliferation and migration. Although the existing evidence supports a beneficial effect of statins on vein grafts biology, more clinical trials focused on the effect of aggressive statin treatment on vein graft patency are required, in order to safely translate this strategy into clinical practice. |
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Authors:
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Marios Margaritis; Keith M Channon; Charalambos Antoniades |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-02-10 |
Journal Detail:
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Title: Current opinion in pharmacology Volume: 12 ISSN: 1471-4973 ISO Abbreviation: Curr Opin Pharmacol Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-06-04 Completed Date: 2012-09-18 Revised Date: 2013-02-28 |
Medline Journal Info:
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Nlm Unique ID: 100966133 Medline TA: Curr Opin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 172-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Cardiovascular Medicine, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Headley way, Oxford OX3 9DU, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Artery Bypass* Graft Occlusion, Vascular / prevention & control* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Saphenous Vein / transplantation Thrombosis / prevention & control Vascular Patency / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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FS/11/66/28855//British Heart Foundation; FS/11/66/28855//British Heart Foundation |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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