Document Detail

Statins--similarities and differences.
MedLine Citation:
PMID:  11383374     Owner:  NLM     Status:  MEDLINE    
The number of statins available to physicians continues to grow, leading to the question: Are all statins alike? Comparisons of side effects and safety profiles and the dose-response relationship among the different drugs show similar results. The cholesterol-lowering action of each depends on its ability to lower low-density lipoprotein cholesterol (LDL-C). On the other hand, the molecular structures of the newer statins are not similar and could have an effect on the mechanism of action of the compounds. Differences in metabolism also suggest the possibility of serious drug-drug interactions, and differences in levels of lipid reduction at varying dosages among the statins point to clinical variation as well.
T Pedersen; A Gaw
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  The American journal of managed care     Volume:  7     ISSN:  1088-0224     ISO Abbreviation:  Am J Manag Care     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-31     Completed Date:  2001-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9613960     Medline TA:  Am J Manag Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S132-7     Citation Subset:  H    
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MeSH Terms
Anticholesteremic Agents / adverse effects,  pharmacology*,  therapeutic use
Coronary Disease / etiology,  prevention & control
Hypercholesterolemia / complications,  drug therapy
Lipoproteins, LDL / blood
Lovastatin / adverse effects,  pharmacology,  therapeutic use
Structure-Activity Relationship
United States
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Lipoproteins, LDL; 75330-75-5/Lovastatin

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