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Statins reverse renal inflammation and endothelial dysfunction induced by chronic high salt intake.
MedLine Citation:
PMID:  21543414     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
High salt intake (HS) is a risk factor for cardiovascular and kidney disease. Indeed, HS may promote blood-pressure-independent tissue injury via inflammatory factors. The lipid lowering 3-hydroxy 3-methylglutaryl-coenzyme A (HMG CoA) reductase inhibitors exert beneficial lipid-independent effects, reducing the expression and synthesis of inflammatory factors. We hypothesized that HS impairs kidney structure and function in the absence of hypertension and these changes are reversed by atorvastatin. Four groups of rats were treated for 6 week in metabolic cages with their diets: Normal salt (NS); HS, NS plus Atorvastatin and HS plus Atorvastatin. We measured basal and final body weight, urinary sodium and protein excretion (U(Prot)V) and systolic blood pressure (SBP). At the end of the experimental period, cholesterolemia, creatinine clearance, renal vascular reactivity, glomerular volume, cortical and glomerular eNOS and TGF-β1 expression were measured. We found no differences in SBP, body weight, and cholesterolemia. HS had increased creatinine clearence, UProtV, glomerular volume at the end of the study. Acetylcholine-induced vasodilatation decreased by 40.4 % in the HS (p < 0.05). The HS decreased cortical and glomerular eNOS and caused mild glomerular sclerosis, interstitial mononuclear cell infiltration and increased cortical expression of TGF-β1. All of these salt-induced changes were reversed by Atorvastatin. We conclude that long term HS induces inflammatory and hemodynamic changes in the kidney that are independent from SBP. Atorvastatin corrected all suggesting that the NO-oxidative stress balance plays a significant role in the earlier stages of salt induced kidney damage.
Authors:
Maria Cecilia Fiore; Pablo Martin Jimenez; David Cremonessi; Luis I Juncos; Nestor H Garcia
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-4
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  -     ISSN:  1522-1466     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Universidad Nacional de San Luis.
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