| Statins and interstitial lung disease: a systematic review of the literature and of food and drug administration adverse event reports. | |
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MedLine Citation:
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PMID: 18689579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To systematically review all published case reports and the US Food and Drug Administration adverse event reporting (FDA-AER) database to examine the relationship between statins and interstitial lung disease (ILD). DATA SOURCES: PubMed (1987 to September 2007) and the FDA-AER database (as of June 2007) were searched for reports of ILD in which a statin was listed as a causative suspect. REVIEW METHODS: Two authors (one author for Pub Med cases and one for FDA-AER cases) independently abstracted patient data. Given the paucity of information, all case reports and case series in English and French were included. All adverse event reports from the FDA-AER database in which a statin was listed as causative suspect were included. RESULTS: The literature search using PubMed yielded eight articles describing a total of 14 case reports of ILD in association with statin use. The FDA-AER system database contained 162 cases of reported statin-induced ILD as of June 2007. For every 10,000 reports of a statin-associated adverse event, approximately 1 to 40 reports were for ILD. CONCLUSIONS: Statin-induced ILD is a possible newly recognized side effect of statin therapy. The mechanism of lung injury is not defined. The current review provides novel information from the FDA-AER that supports a possible, although unusual, pulmonary class effect of statins. |
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Authors:
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Antonio B Fernández; Richard H Karas; Alawi A Alsheikh-Ali; Paul D Thompson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-08-08 |
Journal Detail:
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Title: Chest Volume: 134 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-09 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 824-30 Citation Subset: AIM; IM |
Affiliation:
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Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adverse Drug Reaction Reporting Systems* Aged Aged, 80 and over Databases, Factual Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects* Hyperlipidemias / complications, drug therapy, epidemiology Lung Diseases, Interstitial / chemically induced*, diagnosis, epidemiology* Male Middle Aged Risk Factors United States / epidemiology United States Food and Drug Administration |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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