Document Detail

Statins induce the regression of left ventricular mass in patients with angina.
MedLine Citation:
PMID:  14745145     Owner:  NLM     Status:  MEDLINE    
Background There is evidence that statins induce the regression of cardiac hypertrophy in a transgenic rabbit model of hypertrophic cardiomyopathy. Methods and Results The association between treatment with statins and the regression of cardiac mass (left ventricular mass index, LVMI) was investigated in a case - control study using transthoracic echocardiography in 304 patients with angina who underwent coronary angiography. Those who received pravastatin or simvastatin were defined as cases (n=66), and age, sex and body mass index-matched controls (n=127) were selected. The cases showed a significant decrease in LVMI compared with the controls. Although the cases included a significantly higher percentage of patients with hypertension and calcium antagonist (CaA) treatment than the controls, there were no relationships between LVMI and either hypertension or CaA treatment. Because the cases had a significantly higher number of stenosed vessels than the controls, LVMI for each number of stenosed vessels was analyzed, and a significant interaction effect between the association of LVMI with statin and the number of stenosed vessels was found. Conclusions Treatment with statins was associated with a lower cardiac mass in patients with angina, suggesting that this is one of the drugs' pleiotropic effects.
Hiroaki Nishikawa; Shin-ichiro Miura; Bo Zhang; Hideki Shimomura; Hidekazu Arai; Yoshihiro Tsuchiya; Kunihiro Matsuo; Keijiro Saku
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  68     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-27     Completed Date:  2004-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  IM    
Department of Cardiology, Fukuoka University School of Medicine, Japan.
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MeSH Terms
Angina Pectoris / drug therapy*
Calcium Channel Blockers
Cardiomegaly / drug therapy*
Case-Control Studies
Constriction, Pathologic
Drug Evaluation
Heart Ventricles / drug effects*,  pathology
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology,  therapeutic use*
Middle Aged
Pravastatin / pharmacology,  therapeutic use
Retrospective Studies
Simvastatin / pharmacology,  therapeutic use
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 79902-63-9/Simvastatin; 81093-37-0/Pravastatin

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