| Statins in the treatment of central nervous system autoimmune disease. | |
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MedLine Citation:
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PMID: 16860400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, are widely prescribed for their cholesterol-lowering properties to reduce atherogenesis and cardiovascular morbidity. Over recent years, statins have also been shown to exert pleiotropic immunomodulatory effects that might be of therapeutic benefit in autoimmune disorders. The primary mechanism by which statins alter immune function appears to be mediated through the inhibition of post-translational protein prenylation of small GTP-binding proteins and is largely independent of lipid-lowering. In experimental autoimmune encephalomyelitis (EAE), the mouse model for multiple sclerosis (MS), statins prevent or reverse paralysis and were recently shown to exert synergistic benefit when combined with agents approved for MS therapy. Based primarily upon the beneficial effects in EAE, statins are now being tested in patients in MS clinical trials. |
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Authors:
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Martin S Weber; Sawsan Youssef; Shannon E Dunn; Thomas Prod'homme; Oliver Neuhaus; Olaf Stuve; John Greenwood; Lawrence Steinman; Scott S Zamvil |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2006-07-24 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 178 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-05 Completed Date: 2006-11-14 Revised Date: 2011-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 140-8 Citation Subset: IM |
Affiliation:
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Department of Neurology and Program in Immunology, University of California, San Francisco, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen Presentation / drug effects Autoimmune Diseases of the Nervous System / drug therapy* Brain / drug effects, immunology Clinical Trials as Topic Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Signal Transduction / immunology* Spinal Cord / drug effects, immunology T-Lymphocytes / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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675//Multiple Sclerosis Society; R01 AI05709/AI/NIAID NIH HHS; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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