Document Detail


Statins in coronary bypass surgery: rationale and clinical use.
MedLine Citation:
PMID:  14667669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Statin therapy prevents the first occurrence and recurrence of coronary events and reduces cardiovascular and general mortality in patients with coronary artery disease. These compounds modulate a variety of processes involved in the pathophysiology of arteriosclerosis and vascular graft disease by lipid-dependent and lipid-independent (pleiotropic) mechanisms. As a result, statins produce angiographic and clinical benefits in patients undergoing coronary bypass surgery. We review the present knowledge about the effects of statins on this pathologic condition and the evidence supporting an early treatment initiation.
Authors:
José Pablo Werba; Elena Tremoli; Paola Massironi; Marina Camera; Aldo Cannata; Francesco Alamanni; Paolo Biglioli; Alessandro Parolari
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  76     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-11     Completed Date:  2004-01-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2132-40     Citation Subset:  AIM; IM    
Affiliation:
Atherosclerosis Unit, Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis / physiopathology
Coronary Artery Bypass*
Coronary Disease / drug therapy,  physiopathology*,  surgery
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology,  therapeutic use*
Recurrence
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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