| Statins in acute coronary syndromes. | |
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MedLine Citation:
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PMID: 22124628 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Statins are the main resource available to reduce LDL-cholesterol levels. Their continuous use decreases cardiovascular morbidity and mortality due to atherosclerosis. The administration of these medications demonstrated to be effective in primary and secondary prevention clinical trials in low and high risk patients. Specialists believe that a possible benefit of hypolipidemic therapy in preventing complications of atherosclerotic diseases is in the reduction of deposition of atherogenic lipoproteins in vulnerable areas of the vasculature. Experimental studies with statins have shown an enormous variety of other effects that could extend the clinical benefit beyond the lipid profile modification itself. Statinbased therapies benefit other important components of the atherothrombotic process: inflammation, oxidation, coagulation, fibrinolysis, endothelial function, vasoreactivity and platelet function. The demonstration of the effects that do not depend on cholesterol lowering or the pleiotropic effects of statins provides the theoretical basis for their potential role as adjunctive therapy in acute coronary syndromes. Retrospective analyses of a variety of studies indicate the potential benefit of statins during acute coronary events. Recent clinical studies have addressed this important issue in prospective controlled trials showing strong evidence for the administration of statins as adjunctive therapy in acute coronary syndromes. |
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Authors:
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Alexandre Russo Sposito; Gentil Barreira de Aguiar Filho; Amanda Rezende Aarão; Francisco Thiago Tomaz de Sousa; Marcelo Chiara Bertolami |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Arquivos brasileiros de cardiologia Volume: 97 ISSN: 1678-4170 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421031 Medline TA: Arq Bras Cardiol Country: - |
Other Details:
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Languages: SPA; ENG; POR Pagination: 350-356 Citation Subset: - |
Affiliation:
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Instituto Dante Pazzanese de Cardiologia, Secretaria de Estado da Saúde de São Paulo, SP, Brasil. |
Vernacular Title:
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Estatinas nas síndromes coronarianas agudas. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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