| Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro. | |
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MedLine Citation:
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PMID: 16428899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence suggests that statins improve the status of patients with coronary artery disease not only by reducing cholesterol levels, but also by acting at the level of the endothelium-smooth muscle unit. Previous results from our laboratory showed that these drugs interact with the vascular wall by partially inhibiting calcium-dependent, agonist-induced contractions in rat aortas. To evaluate whether this effect is also extended to the coronary vasculature, we assessed the effect of statins on serotonin (5-HT) induced contractions of left and right coronary arteries of swine. Concentration-response curves for the 5-HT-induced contractions (from 0.1 nmol/l to 100 micromol/l) were calculated on rings from both coronaries in the presence and absence of either (5 micromol/l) pravastatin, mevastatin, simvastatin, lovastatin, or atorvastatin. After a 45-min incubation period, all statins significantly reduced the Emax for the 5-HT-induced contractions, ranging from 51.9 +/- 1.9% (simvastatin) to 15.9 +/- 2.0% (pravastatin) in the left coronary artery and from 48.8 +/- 2.0% (simvastatin) to 17.8 +/- 2.5% (pravastatin) in the right coronary artery. The EC50 values for the 5-HT-induced contractions were 0.150 +/- 0.005 micromol/l for the left coronary artery and 0.171 +/- 0.010 micromol/l for the right coronary artery. These values significantly changed after incubation with statins, ranging from 1.240 +/- 0.101 micromol/l (for simvastatin) to 0.081+/- 0.008 micromol/l (for pravastatin) in the left coronary artery and from 1.410 +/- 0.075 micromol/l (for simvastatin) to 0.084 +/- 0.008 micromol/l (for pravastatin) in the right coronary artery. This evidence supports the possibility that, beyond their lipid-lowering properties, statins may provide a beneficial effect in atherosclerotic patients by reducing the tone in the coronary vasculature, facilitating blood flow to the myocardium. |
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Authors:
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Maria J Crespo; José A Quidgley |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Extramural Date: 2006-01-20 |
Journal Detail:
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Title: Pharmacology Volume: 76 ISSN: 0031-7012 ISO Abbreviation: Pharmacology Publication Date: 2006 |
Date Detail:
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Created Date: 2006-02-21 Completed Date: 2006-04-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 141-7 Citation Subset: IM |
Copyright Information:
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Copyright 2006 S. Karger AG, Basel. |
Affiliation:
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Department of Physiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. mcrespo@rcm.upr.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Vessels / drug effects*, physiology Dose-Response Relationship, Drug Heptanoic Acids / pharmacology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology* Lovastatin / analogs & derivatives, pharmacology Male Pravastatin / pharmacology Pyrroles / pharmacology Serotonin / pharmacology* Simvastatin / pharmacology Swine Time Factors Vasoconstriction / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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2 SO6 GM08224/GM/NIGMS NIH HHS; RR-03051/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 50-67-9/Serotonin; 73573-88-3/compactin; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin; 81093-37-0/Pravastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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