Document Detail


Statins decrease adverse outcomes in coronary artery bypass for extensive coronary artery disease as well as left main coronary stenosis.
MedLine Citation:
PMID:  20398095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate the effects of preoperative and postoperative statins on coronary artery bypass grafting (CABG) for extensive coronary artery disease as well as left main coronary stenosis (LMS). The data of 626 cases of extensive coronary artery disease as well as LMS patients in Anzhen Hospital between January 1998 and March 2008 for CABG procedure were retrospectively analyzed, and were classified as preoperative statin therapy group (Group A, n = 320) or preoperative no statin therapy group (Group B, n = 306). Propensity scores were estimated to determine the probability of inclusion into statin therapy group, resulting in the successful matching of 267 pairs. The incidence of in-hospital death, and atrial fibrillation or flutter and disabling stroke was higher in Group B than in Group A. The actuarial freedom from late events at 5 yrs were 98.75%+/- 0.73% for the postoperative statin therapy group and 88.33%+/- 3.71% for the postoperative no statin therapy group respectively, P= 0.000. The logistic regression revealed that CRP (>5.0 mg/L), and elevated Troponin I, and emergent procedure, and preoperative IABP support, and EF < 40% were the independent risk factors, and preoperatively statins was the protective factor for the perioperative death; and the Cox proportional hazard also revealed that preoperative IABP support and preoperative cardiac arrest, and EF < 40% were independent risk factors, and postoperatively statins were the protective factor for the late cardiac events. Preoperative statin therapy could provide protective effect in the perioperative period. Postoperative statin usage could provide protective effect on the late cardiac events.
Authors:
Hui-Li Gan; Jian-Qun Zhang; Ping Bo; Sheng-Xun Wang; Chun-Shang Lu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular therapeutics     Volume:  28     ISSN:  1755-5922     ISO Abbreviation:  Cardiovasc Ther     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101319630     Medline TA:  Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  70-9     Citation Subset:  IM    
Affiliation:
Cardiac Surgery Department, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing 100029, China. ganhuili@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Atrial Fibrillation / etiology,  prevention & control
Atrial Flutter / etiology,  prevention & control
Cardiovascular Diseases / etiology,  mortality,  prevention & control*
Chi-Square Distribution
China
Coronary Artery Bypass / adverse effects*,  mortality
Coronary Stenosis / mortality,  surgery*
Female
Hospital Mortality
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Kaplan-Meiers Estimate
Logistic Models
Male
Middle Aged
Odds Ratio
Perioperative Care
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Risk Factors
Stroke / etiology,  prevention & control
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors
Comments/Corrections
Comment In:
Cardiovasc Ther. 2010 Apr;28(2):67-9   [PMID:  20398094 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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