Document Detail

Statins as antiarrhythmics: a systematic review part I: effects on risk of atrial fibrillation.
MedLine Citation:
PMID:  19911349     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent studies have demonstrated that statins may possess antiarrhythmic properties in addition to their lipid-lowering effects. METHODS: Studies which reported the association of statins with the incidence of atrial arrhythmias were identified through a systematic review of published literature. RESULTS: One randomized, placebo-controlled trial of 200 patients undergoing cardiac surgery showed that atorvastatin decreased the incidence of postoperative atrial fibrillation by 61%. Observational studies in patients with stable coronary disease, left ventricular dysfunction, or those undergoing cardiac or noncardiac surgery show that statin therapy is associated with an approximately 50% lower rate of atrial fibrillation. Two small randomized trials reported conflicting results: one showing that atorvastatin reduced the recurrence of AF after electrical cardioversion and the other finding that pravastatin did not. CONCLUSIONS: Published data suggests that statins may possess antiarrhythmic properties that reduce the propensity for atrial fibrillation. Most of this data is observational; more randomized, placebo-controlled trials are needed.
Hussam Abuissa; James H O'Keefe; Kevin A Bybee
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical cardiology     Volume:  32     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  544-8     Citation Subset:  IM    
University of Missouri, Kansas City, Missouri, USA.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use*
Atrial Fibrillation / etiology,  prevention & control*
Evidence-Based Medicine
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Recurrence / prevention & control
Risk Factors
Treatment Outcome
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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