Document Detail


Statins as anti-arrhythmics: a systematic review part II: effects on risk of ventricular arrhythmias.
MedLine Citation:
PMID:  19816987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent studies have demonstrated that statins may possess anti-arrhythmic properties in addition to their lipid-lowering effects. METHODS: Studies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature. RESULTS: Statins have been associated with a significant reductions in ventricular arrhythmia in cardiomyopathy patients with an implantable cardioverter defibrillator, although randomized trials have not been completed. CONCLUSIONS: Published data suggests that statins may possess anti-arrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo-controlled trials are needed.
Authors:
Hussam Abuissa; James H O'Keefe; Kevin A Bybee
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical cardiology     Volume:  32     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2010-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  549-52     Citation Subset:  IM    
Affiliation:
University of Missouri, Kansas City, Missouri, USA. abuissa.hussam@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Anti-Arrhythmia Agents / therapeutic use*
Arrhythmias, Cardiac / etiology,  prevention & control*
Combined Modality Therapy
Death, Sudden, Cardiac / etiology,  prevention & control
Defibrillators, Implantable*
Evidence-Based Medicine
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Recurrence / prevention & control
Risk Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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