| Statins and the acute coronary syndrome: 'the early bird catches the worm'. | |
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MedLine Citation:
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PMID: 16805758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The early period following an acute coronary syndrome (ACS) is characterised by atherosclerotic plaque destabilisation and a pro-coagulant state, and is when patients are at highest risk for recurrent cardiovascular events and mortality. Statins decrease thrombus formation and increase fibrinolysis, inhibit platelet reactivity and aggregation, improve endothelial function in patients with coronary artery disease and have a major role in plaque stabilisation. Several studies showed that initiation of early statin therapy in these settings may have beneficial effects. This review summarises the current data on statins in the setting of ACSs. Known and other possible mechanisms of action are described. The pathophysiological mechanisms, histological features and biochemical characteristics of ACS are different than those with stable coronary disease, thereby suggesting that the mechanisms whereby statins exert their benefits in ACS may be distinct from those for stable CHD. Initiation of the therapy during hospitalisation rather than at the time of hospital discharge may provide protection against early recurrent cardiovascular events and also improve patients' compliance. |
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Authors:
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P Nair; A Roguin |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of clinical practice Volume: 60 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-29 Completed Date: 2007-04-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 716-27 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Rambam Medical Center, B. Rappaport, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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C-Reactive Protein
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metabolism Cholesterol, LDL / blood Clinical Trials as Topic Coronary Artery Disease / drug therapy, physiopathology Dose-Response Relationship, Drug Endothelium, Vascular / physiopathology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Myocardial Ischemia / drug therapy* Platelet Aggregation Inhibitors / therapeutic use Risk Factors Syndrome Thromboxane A2 / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Platelet Aggregation Inhibitors; 57576-52-0/Thromboxane A2; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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