| Statins and their role in pre-percutaneous coronary intervention. | |
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MedLine Citation:
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PMID: 20440582 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Lipid-lowering therapy with statins reduces the risk of cardiovascular events in patients with coronary artery disease. Recent in vitro and in vivo studies demonstrated a low-density lipoprotein-independent action of this class of drugs, which appears to modulate endothelial function, inflammation, and thrombosis. Randomized studies showed a beneficial effect of short-term statin pretreatment in reducing periprocedural cardiac marker release in patients undergoing percutaneous coronary intervention (PCI). In particular, the ARMYDA (Atorvastatin for Reduction of Myocardial Damage During Angioplasty) investigators--initially in stable angina patients, then in patients with acute coronary syndrome, and then in patients already on chronic statin therapy--demonstrated an improvement in 30-day major adverse cardiac event rates, which were driven by a reduced rate of periprocedural myocardial infarction. Moreover, statin therapy at the time of PCI significantly decreased the incidence of contrast-induced nephropathy. These observations support high-dose statin pretreatment in all patients who are candidates for PCI. |
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Authors:
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Rosetta Melfi; Annunziata Nusca; Giuseppe Patti; Germano Di Sciascio |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current cardiology reports Volume: 12 ISSN: 1534-3170 ISO Abbreviation: Curr Cardiol Rep Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 295-301 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Sciences, Campus Bio-Medico University, Via Alvaro del Portillo 200, 00128, Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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