Document Detail


Statins and their role in pre-percutaneous coronary intervention.
MedLine Citation:
PMID:  20440582     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Lipid-lowering therapy with statins reduces the risk of cardiovascular events in patients with coronary artery disease. Recent in vitro and in vivo studies demonstrated a low-density lipoprotein-independent action of this class of drugs, which appears to modulate endothelial function, inflammation, and thrombosis. Randomized studies showed a beneficial effect of short-term statin pretreatment in reducing periprocedural cardiac marker release in patients undergoing percutaneous coronary intervention (PCI). In particular, the ARMYDA (Atorvastatin for Reduction of Myocardial Damage During Angioplasty) investigators--initially in stable angina patients, then in patients with acute coronary syndrome, and then in patients already on chronic statin therapy--demonstrated an improvement in 30-day major adverse cardiac event rates, which were driven by a reduced rate of periprocedural myocardial infarction. Moreover, statin therapy at the time of PCI significantly decreased the incidence of contrast-induced nephropathy. These observations support high-dose statin pretreatment in all patients who are candidates for PCI.
Authors:
Rosetta Melfi; Annunziata Nusca; Giuseppe Patti; Germano Di Sciascio
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  12     ISSN:  1534-3170     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-301     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Sciences, Campus Bio-Medico University, Via Alvaro del Portillo 200, 00128, Rome, Italy.
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