Document Detail


Statin use and lipid profile in relation to safety and functional outcome after thrombolysis in ischemic stroke.
MedLine Citation:
PMID:  23002934     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Evaluation of: Rocco A, Sykora M, Ringleb P, Diedler J. Impact of statin use and lipid profile on symptomatic intracerebral haemorrhage, outcome and mortality after intravenous thrombolysis in acute stroke. Cerebrovasc. Dis. 33(4), 362-368 (2012). Statins are widely used in the primary and secondary prevention of cardiovascular disease and prevent first and recurrent ischemic strokes mainly because of their lipid-lowering effect. However, they also have pleiotropic effects and might be neuroprotective in acute ischemic stroke. Improved functional outcome in patients with acute ischemic stroke treated with intravenous thrombolysis tissue plasminogen activator has been proposed, but not confirmed by other studies. Furthermore, some studies showed an increased risk of symptomatic intracranial hemorrhage in statin users. The article being evaluated presents a large observational cohort of acute ischemic stroke patients treated with intravenous tissue plasminogen activator and showed no association between statin use or lipid profiles and functional outcome or risk of symptomatic intracranial hemorrhage. The results of this article are discussed in the context of previous published studies.
Authors:
Irene Miedema; Maarten Uyttenboogaart; Gert-Jan Luijckx
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of neurotherapeutics     Volume:  12     ISSN:  1744-8360     ISO Abbreviation:  Expert Rev Neurother     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129944     Medline TA:  Expert Rev Neurother     Country:  England    
Other Details:
Languages:  eng     Pagination:  907-10     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
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