| Statin use is associated with enhanced collateralization of severely diseased coronary arteries. | |
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MedLine Citation:
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PMID: 14597938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The presence of coronary collateral vessels has been associated with improved clinical outcome in patients with coronary artery disease. Animal experiments have shown that hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) can promote angiogenesis in ischemic tissues in a cholesterol-independent manner. We hypothesized that statin therapy is associated with increased coronary collateral formation in patients with severe coronary artery disease. METHODS AND RESULTS: Patients undergoing clinically indicated coronary angiography at the Tufts-New England Medical Center from September 2000 to April 2001 who had at least 1 major coronary artery occlusion, or a stenosis of > or =95% with Thrombolysis In Myocardial Infarction (TIMI) trial grade < or =1 anterograde flow on their angiograms, were included. Fifty-one patients were taking statins before admission, and 43 patients were not. Their angiograms were reviewed and coronary collaterals were graded from 0 to 3 according to the Cohen-Rentrop method. The statin-treated group had a significantly higher mean collateral score compared with the patients not taking statins (2.05 vs 1.52, P =.005). Multivariate analysis supported the significance of the effect of statin therapy on the collateral score. There was no relation between collateral score and low-density lipoprotein levels (r = -0.06, P =.64). The statin-treated group also had a significantly higher left ventricular ejection fraction compared to the patients not taking statins (51% vs 44%, P <.05). CONCLUSIONS: Statin therapy is associated with enhanced coronary collateral formation in patients with severely diseased coronary arteries. |
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Authors:
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Isaac Pourati; Carey Kimmelstiel; William Rand; Richard H Karas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 146 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-04 Completed Date: 2004-02-25 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 876-81 Citation Subset: AIM; IM |
Affiliation:
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Preventive Cardiology Center, Division of Cardiology, and Department of Medicine, New England Medical Center Hospitals, Boston, Mass, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aspirin / administration & dosage Calcium Channels / administration & dosage Collateral Circulation / drug effects Coronary Angiography* Coronary Disease / drug therapy*, physiopathology*, radiography Drug Therapy, Combination Female Heptanoic Acids / administration & dosage Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Male Middle Aged Multivariate Analysis Neovascularization, Pathologic / drug therapy Pyrroles / administration & dosage Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 50-78-2/Aspirin |
| Comments/Corrections | |
Comment In:
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Am Heart J. 2004 Nov;148(5):e21
[PMID:
15523299
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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