Document Detail

Statin use is associated with enhanced collateralization of severely diseased coronary arteries.
MedLine Citation:
PMID:  14597938     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The presence of coronary collateral vessels has been associated with improved clinical outcome in patients with coronary artery disease. Animal experiments have shown that hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) can promote angiogenesis in ischemic tissues in a cholesterol-independent manner. We hypothesized that statin therapy is associated with increased coronary collateral formation in patients with severe coronary artery disease. METHODS AND RESULTS: Patients undergoing clinically indicated coronary angiography at the Tufts-New England Medical Center from September 2000 to April 2001 who had at least 1 major coronary artery occlusion, or a stenosis of > or =95% with Thrombolysis In Myocardial Infarction (TIMI) trial grade < or =1 anterograde flow on their angiograms, were included. Fifty-one patients were taking statins before admission, and 43 patients were not. Their angiograms were reviewed and coronary collaterals were graded from 0 to 3 according to the Cohen-Rentrop method. The statin-treated group had a significantly higher mean collateral score compared with the patients not taking statins (2.05 vs 1.52, P =.005). Multivariate analysis supported the significance of the effect of statin therapy on the collateral score. There was no relation between collateral score and low-density lipoprotein levels (r = -0.06, P =.64). The statin-treated group also had a significantly higher left ventricular ejection fraction compared to the patients not taking statins (51% vs 44%, P <.05). CONCLUSIONS: Statin therapy is associated with enhanced coronary collateral formation in patients with severely diseased coronary arteries.
Isaac Pourati; Carey Kimmelstiel; William Rand; Richard H Karas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  146     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-04     Completed Date:  2004-02-25     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  876-81     Citation Subset:  AIM; IM    
Preventive Cardiology Center, Division of Cardiology, and Department of Medicine, New England Medical Center Hospitals, Boston, Mass, USA.
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MeSH Terms
Aspirin / administration & dosage
Calcium Channels / administration & dosage
Collateral Circulation / drug effects
Coronary Angiography*
Coronary Disease / drug therapy*,  physiopathology*,  radiography
Drug Therapy, Combination
Heptanoic Acids / administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Middle Aged
Multivariate Analysis
Neovascularization, Pathologic / drug therapy
Pyrroles / administration & dosage
Retrospective Studies
Reg. No./Substance:
0/Calcium Channels; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 50-78-2/Aspirin
Comment In:
Am Heart J. 2004 Nov;148(5):e21   [PMID:  15523299 ]

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