| Statin therapy: a potentially useful peri-operative intervention in patients with cardiovascular disease. | |
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MedLine Citation:
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PMID: 16229696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Statin cardiovascular protection is mediated by lipid lowering and pleiotropic effects. The efficacy of statins has been established in non-surgical patients with cardiovascular disease and also more recently in non-surgical patients who sustain an acute coronary event. Peri-operative statin administration has been shown to improve both short-term and long-term cardiac outcome following non-cardiac and coronary bypass graft surgery. This cardioprotection may be independent of peri-operative haemodynamics due to a positive effect on plaque stability. Recommendations for the peri-operative statin administration are suggested. These include indications for peri-operative statin therapy, timing of administration, therapeutic targets, duration of administration, the adverse implications of peri-operative statin withdrawal, safety and cost-effectiveness. |
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Authors:
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B M Biccard; J W Sear; P Foëx |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anaesthesia Volume: 60 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-18 Completed Date: 2005-11-15 Revised Date: 2006-03-23 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 1106-14 Citation Subset: AIM; IM |
Affiliation:
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Clinical Research Fellow, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK. bruce.biccard@nda.ox.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antilipemic Agents
/
adverse effects,
therapeutic use* Cardiovascular Diseases / prevention & control* Drug Administration Schedule Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects, therapeutic use* Perioperative Care / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| Comments/Corrections | |
Comment In:
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Anaesthesia. 2006 Mar;61(3):307-8; author reply 308
[PMID:
16480376
]
Anaesthesia. 2006 Mar;61(3):307; author reply 308 [PMID: 16480377 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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