Document Detail

Statin therapy: a potentially useful peri-operative intervention in patients with cardiovascular disease.
MedLine Citation:
PMID:  16229696     Owner:  NLM     Status:  MEDLINE    
Statin cardiovascular protection is mediated by lipid lowering and pleiotropic effects. The efficacy of statins has been established in non-surgical patients with cardiovascular disease and also more recently in non-surgical patients who sustain an acute coronary event. Peri-operative statin administration has been shown to improve both short-term and long-term cardiac outcome following non-cardiac and coronary bypass graft surgery. This cardioprotection may be independent of peri-operative haemodynamics due to a positive effect on plaque stability. Recommendations for the peri-operative statin administration are suggested. These include indications for peri-operative statin therapy, timing of administration, therapeutic targets, duration of administration, the adverse implications of peri-operative statin withdrawal, safety and cost-effectiveness.
B M Biccard; J W Sear; P Foëx
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anaesthesia     Volume:  60     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-18     Completed Date:  2005-11-15     Revised Date:  2006-03-23    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1106-14     Citation Subset:  AIM; IM    
Clinical Research Fellow, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.
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MeSH Terms
Antilipemic Agents / adverse effects,  therapeutic use*
Cardiovascular Diseases / prevention & control*
Drug Administration Schedule
Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects,  therapeutic use*
Perioperative Care / methods*
Treatment Outcome
Reg. No./Substance:
0/Antilipemic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors
Comment In:
Anaesthesia. 2006 Mar;61(3):307-8; author reply 308   [PMID:  16480376 ]
Anaesthesia. 2006 Mar;61(3):307; author reply 308   [PMID:  16480377 ]

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