| Statin therapy in lupus-mediated atherogenesis: two birds with one stone? | |
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MedLine Citation:
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PMID: 21068103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The atherosclerotic process is accelerated in patients with systemic lupus erythematosus (SLE). In addition to a robust lipid-lowering effect, various immunomodulatory functions have been ascribed to statins. By virtue of the latter they may be able to reduce atherosclerotic vascular disease in SLE by inhibiting immune activation within the arterial wall and by attenuating lupus activity. The effects of statins on SLE as well as on lupus-mediated atherogenesis in vivo are discussed in this viewpoint. |
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Authors:
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Sander I van Leuven; Yanice V Mendez-Fernandez; Erik S Stroes; Paul P Tak; Amy S Major |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-11-10 |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 70 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-14 Completed Date: 2011-02-17 Revised Date: 2012-03-21 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 245-8 Citation Subset: IM |
Affiliation:
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Department of Vascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. s.i.vanleuven@amc.uva.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / etiology, prevention & control* Disease Models, Animal Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Lupus Erythematosus, Systemic / complications, drug therapy* Mice |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL088364-01A1/HL/NHLBI NIH HHS; R01 HL088364-02/HL/NHLBI NIH HHS; R01 HL088364-02S1/HL/NHLBI NIH HHS; R01 HL088364-03/HL/NHLBI NIH HHS; R01 HL088364-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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