Document Detail


Statin therapy is associated with reduced total and cardiovascular mortality after coronary artery bypass grafting surgery.
MedLine Citation:
PMID:  19005297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In an observational study, we evaluated the association between postoperative statin therapy and long-term mortality among patients undergoing a first-ever coronary artery bypass grafting (CABG) surgery. METHODS: In an outpatient clinic setting, we assessed 1869 consecutive patients (age 58.7+/-9.6 years; 1657 men), who survived the 1st month after a first-ever CABG, within a 17-year period. Cox proportional hazard analysis was used to calculate the adjusted hazard ratios (adjusting for age, smoking, the presence of hypertension, diabetes mellitus, lipid profile at the time of the procedure, vessel disease, number and kind of grafts used, and concomitant treatment) for patients receiving statin treatment during follow-up and adjusted Kaplan-Meier survival curves were constructed. RESULTS: During a 9345 patient-years follow-up, 48% of the patients were on a statin. In a total of 222 deaths, 80.6% were because of cardiovascular causes. Total and cardiovascular mortality were significantly reduced in patients receiving statin therapy [adjusted hazard ratio, 0.48 (95% confidence interval, 0.28-0.82); P=0.007), and 0.43 (95% confidence interval, 0.23-0.80); P=0.007, respectively]. The estimated 16-year Kaplan-Meier survival curves diverged at 2 years and thereafter. CONCLUSION: Taking into account the potential limitations of observational data, statin treatment postoperatively is associated with a 50% reduction in total and cardiovascular mortality in patients undergoing a first-ever CABG.
Authors:
Athanasios Papathanasiou; Ioannis K Toumpoulis; Haralampos J Milionis; Kallirroi Kalantzi; Christos S Katsouras; John Goudevenos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  19     ISSN:  1473-5830     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-13     Completed Date:  2009-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  619-25     Citation Subset:  IM    
Affiliation:
Department of Cardiology, School of Medicine, University of Ioannina, Ioannina, Greece.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiovascular Diseases / etiology,  mortality,  prevention & control*
Coronary Artery Bypass / adverse effects,  mortality*
Coronary Artery Disease / drug therapy*,  mortality,  surgery*
Female
Greece / epidemiology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Kaplan-Meiers Estimate
Male
Middle Aged
Postoperative Care
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

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