Document Detail


Statin therapy is associated with decreased small, dense low-density lipoprotein levels in patients undergoing peritoneal dialysis.
MedLine Citation:
PMID:  22652726     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cardiovascular disease is a major cause of morbidity and mortality among hemodialysis (HD) and peritoneal dialysis (PD) patients, and dyslipidemia plays an important role in its pathogenesis. In particular, small, dense LDL (sd-LDL) particles have been recently highlighted as an emerging cardiovascular risk factor. PD patients exhibit a more overtly abnormal lipid profile than HD patients, probably due to the metabolic interference of the peritoneal dialysis fluid. Statins are the main drugs for the treatment of dyslipidemia and they are able to decrease all LDL subclasses levels, but it remains unclear whether they can influence the proportion of sd-LDL. Only few studies regarding the effect of statins on the proportion of these particles have been performed in HD patients and, to our knowledge, no trials have been carried out in PD patients. Therefore, we compared the lipid profile and the proportion of sd-LDL in two populations of HD and PD patients. Our study suggests that statin therapy may be effective in reducing both the absolute amount and the proportion of sd-LDL in patients with a more overtly abnormal lipid profile, such as patients undergoing peritoneal dialysis. Statins do not seem to be effective in altering sd-LDL levels in patients undergoing hemodialysis with other factors that can influence LDL subtractions generation, such as hypertension and diabetes mellitus. If and when our results prove to be reproducible in large-scale studies, such studies should provide new insights into sd-LDL and its actual role in atherogenesis in patients undergoing hemodialysis or peritoneal dialysis.
Authors:
Anna Clementi; Jeong Chul Kim; Matteo Floris; Dinna N Cruz; Francesco Garzotto; Monica Zanella; Federico Nalesso; Alessandra Brendolan; Davide Giavarina; Giuliano Soffiati; Claudio Ronco
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Publication Detail:
Type:  Journal Article     Date:  2012-05-25
Journal Detail:
Title:  Contributions to nephrology     Volume:  178     ISSN:  1662-2782     ISO Abbreviation:  Contrib Nephrol     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  111-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy.
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