| Statin loading for acute coronary syndromes. | |
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MedLine Citation:
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PMID: 20520540 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This review discusses the role of statin therapy in patients with acute coronary syndromes. These drugs modulate endothelial function and stabilize atherosclerotic plaque by inhibiting oxidative stress and inflammation and may provide a relevant clinical benefit in unstable patients. RECENT FINDINGS: Conflicting data derive from randomized trials about early statin therapy in medically treated patients with acute coronary syndromes. Results of the ARMYDA studies demonstrate a clear benefit of statin pretreatment in patients with both stable and unstable syndromes undergoing percutaneous coronary revascularization. In the ARMYDA RECAPTURE, even an acute reload with high-dose atorvastatin in patients on top of chronic statin use was associated with a significant reduction of 30-day major adverse cardiac events, especially in those patients who presented with acute coronary syndromes. SUMMARY: All this evidence strongly supports an 'upstream' administration of high-dose statins in patients with acute coronary syndromes treated with an early invasive strategy. |
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Authors:
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Annunziata Nusca; Rosetta Melfi; Giuseppe Patti; Germano Di Sciascio |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in cardiology Volume: 25 ISSN: 1531-7080 ISO Abbreviation: Curr. Opin. Cardiol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608087 Medline TA: Curr Opin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 373-8 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Rome, Italy. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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