Document Detail

Statin-induced rhabdomyolysis: a comprehensive review of case reports.
MedLine Citation:
PMID:  24799748     Owner:  NLM     Status:  PubMed-not-MEDLINE    
PURPOSE: To identify case reports of statin-induced rhabdomyolysis and summarize common predisposing factors, symptoms, diagnostic findings, functional outcomes, characteristics, treatment, and rehabilitation.
METHOD: MEDLINE, CINAHL, SCOPUS, and PEDro databases were searched (1990-2013) for relevant case reports using the search terms "Statins," "Rhabdomyolysis," "Myalgia," "Muscle damage," "Muscle injury," and "Myopathy." Relevance (based on title and abstract) was assessed by one investigator; two investigators independently reviewed the relevant articles to determine inclusion in the review.
RESULTS: A total of 112 cases met the inclusion criteria. The majority were in men (70%) and people over 45 years of age (mean 64 [SD 14] years). Simvastatin was the most commonly reported statin (n=55); the majority of cases reported the use of concomitant medications such as fibrates (n=25). Weakness (n=65) and muscle pain (n=64) were the most common symptoms. In 19 cases, the patient was referred to rehabilitation, but the case reports do not include descriptions of the treatment.
CONCLUSION: Statin-induced rhabdomyolysis was more commonly reported when statins were used in conjunction with other drugs, which potentiated its effect. Research is needed to identify the role of exercise and rehabilitation following statin-induced rhabdomyoloysis since muscle damage may be severe and may have long-term effects on muscle function.
Abstract available from the publisher.
Polyana Mendes; Priscila Games Robles; Sunita Mathur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiotherapy Canada. Physiothérapie Canada     Volume:  66     ISSN:  0300-0508     ISO Abbreviation:  Physiother Can     Publication Date:  2014  
Date Detail:
Created Date:  2014-05-06     Completed Date:  2014-05-06     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  0346574     Medline TA:  Physiother Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  124-32     Citation Subset:  -    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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