Document Detail


Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
MedLine Citation:
PMID:  18608208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Statins have antiproliferative and anti-tumoral effects in MCF-7 cells. We determined the effect of statins upon MCF-7 cell cycle, toxicity, cell death, reactive oxygen species (ROS) production and mitochondrial membrane potential. Fluvastatin, simvastatin and atorvastatin inhibited cell proliferation. Antiproliferation was associated with a decrease in the DNA synthesis and a cell cycle arrest in the G1 and G2/M phases. A loss in the mitochondrial membrane potential was observed with fluvastatin. Statins induced increase in ROS production that was associated with cell death, which was abrogated by the antioxidant NAC. Our results suggest that the cytotoxic effect observed is mediated by an oxidative stress.
Authors:
Claudia A Sánchez; Emma Rodríguez; Elvira Varela; Estrella Zapata; Araceli Páez; Felipe A Massó; Luis F Montaño; Rebeca Lóopez-Marure
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer investigation     Volume:  26     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-30     Completed Date:  2008-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  698-707     Citation Subset:  IM    
Affiliation:
Departamento de Biologia Celular, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / pharmacology
Antineoplastic Agents / pharmacology*
Antioxidants / pharmacology
Apoptosis / drug effects*
Breast Neoplasms / metabolism,  pathology*
Cell Cycle / drug effects*
Cell Line, Tumor
Cell Membrane / drug effects
Cell Proliferation / drug effects
DNA Replication / drug effects
Dose-Response Relationship, Drug
Fatty Acids, Monounsaturated / pharmacology
Female
Heptanoic Acids / pharmacology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
Indoles / pharmacology
Membrane Potential, Mitochondrial / drug effects
Necrosis
Oxidative Stress / drug effects*
Pyrroles / pharmacology
Reactive Oxygen Species / metabolism
Simvastatin / pharmacology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antioxidants; 0/Fatty Acids, Monounsaturated; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Indoles; 0/Pyrroles; 0/Reactive Oxygen Species; 110862-48-1/atorvastatin; 616-91-1/Acetylcysteine; 79902-63-9/Simvastatin; 93957-54-1/fluvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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