Document Detail


Statin-fibrate combination for mixed dyslipidaemia: a limited option?
MedLine Citation:
PMID:  20662560     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abstract A growing body of evidence suggests that targeting low-density lipoprotein cholesterol is not enough and that a substantial residual risk remains despite aggressive statin treatment, particularly in patients with mixed dyslipidemia. Statin plus fibrate combination results in a more effective control of several lipid parameters than either monotherapy with a safety profile similar to both monotherapies. Therefore, this combination might represent a therapeutic option for selected patients with mixed dyslipidemia. However, the clinical benefit of statin/fibrate combination has only been observed in small subgroup analyses and more data are needed before a wider implementation is recommended in everyday clinical practice.
Authors:
Vasilios G Athyros; Konstantinos Tziomalos; Asterios Karagiannis; Dimitri P Mikhailidis
Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  Current medical research and opinion     Volume:  26     ISSN:  1473-4877     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  England    
Other Details:
Languages:  eng     Pagination:  2137-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Choice Behavior
Drug Combinations
Dyslipidemias / drug therapy*
Fibric Acids / administration & dosage*,  adverse effects
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*,  adverse effects
Hypolipidemic Agents / administration & dosage,  adverse effects
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Fibric Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Hypolipidemic Agents
Comments/Corrections
Comment On:
Curr Med Res Opin. 2010 Sep;26(9):2141-6   [PMID:  20662558 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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