Document Detail

Statin-associated necrotizing autoimmune myopathy.
MedLine Citation:
PMID:  23377697     Owner:  NLM     Status:  Publisher    
Necrotizing autoimmune myopathy (NAM) is a severe adverse effect of statins. We report a 66-year-old Caucasian female who had progressive proximal muscle weakness after treatment with statins. Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen expression in muscle fibers. The clinical and laboratory parameters improved significantly with immunosuppressive treatment. Although it is a rare event, statin-induced NAM should be included as a differential diagnosis of myopathies.
Geórgea Hermogenes Fernandes; Edmar Zanoteli; Samuel Katsuyuki Shinjo
Related Documents :
23697797 - Aging increases the oxidation of dichlorohydrofluorescein in single isolated skeletal m...
23508137 - Comparison of morphometric aspects of light and electron microscopy of the hypoglossal ...
7396227 - Anatomical studies on the pudendal nerve in the indian buffalo (bubalus bubalis).
24939997 - Skeletal muscle lipid content and oxidative activity in relation to muscle fiber type i...
9415827 - Lactate transport and lactate transporters in skeletal muscle.
7234947 - Acquired blepharoptosis secondary to contact-lens wear.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-4
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  -     ISSN:  1439-7609     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455-3º andar, sala 3150, São Paulo, CEP 01246-903, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Postmarketing safety surveillance : where does signal detection using electronic healthcare records ...
Next Document:  Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review an...