| Statin-associated necrotizing autoimmune myopathy. | |
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MedLine Citation:
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PMID: 23377697 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Necrotizing autoimmune myopathy (NAM) is a severe adverse effect of statins. We report a 66-year-old Caucasian female who had progressive proximal muscle weakness after treatment with statins. Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen expression in muscle fibers. The clinical and laboratory parameters improved significantly with immunosuppressive treatment. Although it is a rare event, statin-induced NAM should be included as a differential diagnosis of myopathies. |
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Authors:
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Geórgea Hermogenes Fernandes; Edmar Zanoteli; Samuel Katsuyuki Shinjo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-4 |
Journal Detail:
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Title: Modern rheumatology / the Japan Rheumatism Association Volume: - ISSN: 1439-7609 ISO Abbreviation: Mod Rheumatol Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959226 Medline TA: Mod Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455-3º andar, sala 3150, São Paulo, CEP 01246-903, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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