Document Detail


Statin-associated myopathy with normal creatine kinase levels. Case report from a Norwegian family.
MedLine Citation:
PMID:  16218940     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trøseid M, Henriksen OA, Lindal S. Statin-associated myopathy with normal creatine kinase levels - case report from a Norwegian family. APMIS 2005;113:635-7. Recent reports suggest that statins may cause myopathy with normal creatine kinase levels. We describe four related patients with statin-associated muscle symptoms and normal creatine kinase levels. In two out of the four patients (mother and son), pathological findings on EMG suggested myopathy, and muscle biopsies showed evidence of mitochondrial pathology. A third patient (daughter) had slight myopathic findings on EMG and muscle biopsy, but not enough to be classified as pathological. In a fourth patient, there were no pathological findings. Creatine kinase levels were normal and symptoms diminished after discontinuation of drugs in all four patients. Our findings are consistent with other reports of statin-associated myopathy with normal creatine kinase levels. An inherited vulnerability, possibly a mitochondrial pathology, might cause or aggravate symptoms in some patients.
Authors:
Marius Trøseid; Olaf A Henriksen; Sigurd Lindal
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  113     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-12     Completed Date:  2006-01-17     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  635-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Akershus University Hospital, Lørenskog, Norway. troseid@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Creatine Kinase / blood*
Female
Humans
Male
Muscle Cramp / chemically induced
Muscle Weakness / chemically induced
Muscle, Skeletal / drug effects*
Muscular Diseases / blood,  chemically induced*,  prevention & control,  therapy
Norway
Simvastatin / adverse effects*
Chemical
Reg. No./Substance:
79902-63-9/Simvastatin; EC 2.7.3.2/Creatine Kinase

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