| Statin therapy significantly reduces risk of ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator. | |
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MedLine Citation:
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PMID: 21048429 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A few observational studies have shown the protective effect of statins on preventing ventricular tachycardia/ventricular fibrillation (VT/VF). However, the disparate study results prompt further exploration of this concept. We performed a meta-analysis to assess whether statin therapy is associated with a decrease in the incidence or recurrence of VT/VF in patients with an implantable cardioverter-defibrillator (ICD).The MEDLINE® and Cochrane databases were searched from 1980 to July 2009 for studies examining the effect of statins on VT/VF in recipients of ICDs. We retrieved all prospective cohort studies that examined this association. The endpoint was defined as appropriate ICD therapy for VT/VF. The quality of individual studies was assessed using the Newcastle Ottawa Scale.Seven prospective cohort studies met our inclusion criteria with a total of 2278 patients with a mean follow-up of 19.7 months. Pooled analysis of the eligible studies revealed that statin therapy was associated with a 45% reduction in the risk of developing VT/VF in recepients of ICDs [pooled odds ratio (pOR): 0.55; 95% confidence interval: 0.34-0.90; heterogeneity I = 81%, P = 0.02]. In a subgroup analysis, the magnitude of the risk reduction in patients with ischemic cardiomyopathy was 54% (pOR: 0.46, P = 0.05). Sensitivity analysis including studies with higher methodological qualities alone showed a significant protective effect (pOR: 0.48, P = 0.01). There was no evidence of publication bias in the analysis.Our meta-analysis suggests an association between the use of statin and a reduction in the VT/VF occurrence in recipients of ICDs, mainly in patients with ischemic cardiomyopathy. |
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Authors:
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Sony Jacob; Palaniappan Manickam; Ankit Rathod; Apurva Badheka; Luis Afonso; Rajeev Aravindhakshan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of therapeutics Volume: 19 ISSN: 1536-3686 ISO Abbreviation: Am J Ther Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: United States |
Other Details:
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Languages: eng Pagination: 261-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology/Electrophysiology, Department of Internal Medicine, Wayne State University, Detroit, MI. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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