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Statin-Mediated Low-Density Lipoprotein Lowering in Chronic Congestive Heart Failure.
MedLine Citation:
PMID:  23154655     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT:: Many theories and clinical trials have attempted to address the effect of low-density lipoprotein (LDL) lowering in chronic congestive heart failure (CHF). The current evidence suggests that there is no convincing reason for administering statins to patients with nonischemic heart failure. Although they do not reduce the mortality rate, statins reduce LDL cholesterol and may provide some benefit to patients with ischemic heart failure. In contrast, some authors believe that statin therapy may actually worsen outcomes in patients with CHF, especially if there is excessive reduction in LDL cholesterol. This review discusses the theories attempting to link the adverse effects of statin-mediated LDL lowering in CHF to increased levels of endotoxin or reduced levels of coenzyme Q10. In addition, the 2 largest randomized, double-blind, placebo-controlled clinical trials (CORONA and GISSI-HF) were discussed. It is clear that more trials are needed to definitely ascertain the effect of statins on CHF.
Authors:
Constantine E Kosmas; Hassan Alkhawam; Mohammed El-Hunjul; Gabriel Wagman; Mark R Kahn; Kathleen M Grady; Timothy J Vittorio
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  -     ISSN:  1538-2990     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Zena and Michael A. Wiener Cardiovascular Institute (CEK), Mount Sinai School of Medicine, New York, New York; Faculty of Medicine (HA, ME-H), Cairo University, Cairo, Egypt; St. Francis Hospital-The Heart Center (GW, TJV), Division of Cardiology, Center of Advanced Cardiac Therapeutics, Roslyn, New York; Department of Internal Medicine (MRK), Mount Sinai School of Medicine, New York, New York; and Cardiovascular Consultants of Long Island (KMG), PC, New Hyde Park, New York.
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