Document Detail

Static versus dynamic respiratory mechanics for setting the ventilator.
MedLine Citation:
PMID:  11064617     Owner:  NLM     Status:  MEDLINE    
The lower inflection point (LIP) of the inspiratory limb of a static pressure-volume (PV) loop is assumed to indicate the pressure at which most lung units are recruited. The LIP is determined by a static manoeuvre with a PV-history that is different from the PV-history of the actual ventilation. In nine surfactant-deficient piglets, information to allow setting PEEP and VT was obtained, both from the PV-curve and also during ongoing ventilation from the dynamic compliance relationship. According to LIP, PEEP was set at 20 (95% confidence interval 17-22) cm H2O. Volume-dependent dynamic compliance suggested a PEEP reduction (to 15 (13-18) cm H2O). Pulmonary gas exchange remained satisfactory and this change resulted in reduced mechanical stress on the respiratory system, indirectly indicated by volume-dependent compliance being consistently great during the entire inspiration.
M Lichtwarck-Aschoff; V Kessler; U H Sjöstrand; A Hedlund; G Mols; S Rubertsson; A M Markström; J Guttmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  85     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-09     Completed Date:  2000-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  577-86     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care, University Hospital, Uppsala, Sweden.
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MeSH Terms
Bronchoalveolar Lavage
Lung Compliance / physiology
Positive-Pressure Respiration / methods*
Pulmonary Gas Exchange / physiology
Pulmonary Surfactants / deficiency
Respiratory Insufficiency / physiopathology,  therapy*
Respiratory Mechanics / physiology*
Stress, Mechanical
Reg. No./Substance:
0/Pulmonary Surfactants

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