| Static magnetic field blood pressure buffering, baroreflex vs. vascular blood pressure control mechanism. | |
| | |
MedLine Citation:
|
PMID: 20148695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: We compared the effect of static magnetic field (SMF) and verapamil, a potent vascular calcium channel blocking agent, on sudden elevation in blood pressure in conjunction with arterial baroreflex sensitivity (BRS) and microcirculation. MATERIALS AND METHODS: Forty-four experiments were performed on conscious rabbits sedated using pentobarbital intravenous (i.v.) infusion (5 mg kg(-1) h(-1)). Mean femoral artery blood pressure (MAP), heart rate, BRS and ear lobe skin microcirculatory blood flow, estimated using microphotoelectric plethysmography (MPPG), were simultaneously measured after a 40 min exposure of the sinocarotid baroreceptors to 350 mT SMF, generated by Nd(2)-Fe(14)-B magnets, or 30 min of verapamil i.v. administration (20 microg kg(-1) min(-1)). BRS was assessed from heart rate and MAP responses to i.v. bolus of nitroprusside and phenylephrine. RESULTS: The decrease in phenylephrine-induced abrupt elevation in MAP (DeltaMAP(AE)) was significantly larger after verapamil than after SMF exposure. DeltaMAP(AE) inversely correlated with verapamil-induced significant increase in DeltaMPPG (r = 0.53, p < 0.000) and with SMF-induced significant increase in DeltaBRS (r = 0.47, p < 0.016). CONCLUSIONS: Our results suggest that verapamil-potentiated vascular blood pressure buffering mechanism was more effective than SMF-potentiated baroreflex-mediated blood pressure buffering mechanism, and a potential benefit of both approaches in cardiovascular conditions with abrupt high elevation in blood pressure. |
| | |
Authors:
|
Juraj Gmitrov |
Related Documents
:
|
8844965 - Are current hydrophone low frequency response standards acceptable for measuring mechan... 14971875 - Medroxyprogesterone improves cardiac autonomic control in postmenopausal women with res... 20197995 - Pressure dependence of integrated cars power. 18823465 - Post-operative pressure lability and cardiac baroreflex in normotensive patients as a f... 11537125 - European eva decompression sickness risks. 14865 - Lower esophageal sphincter pressure in cirrhotic men with ascites: before and after diu... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of radiation biology Volume: 86 ISSN: 1362-3095 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-12 Completed Date: 2010-03-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: England |
Other Details:
|
Languages: eng Pagination: 89-101 Citation Subset: IM; S |
Affiliation:
|
Department of Environmental Health, The National Institute of Public Health, Tokyo, Japan. gmitrovj@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Baroreflex* / drug effects Blood Pressure* / drug effects Calcium Channel Blockers / pharmacology Heart Rate / drug effects Magnetic Field Therapy* Male Microcirculation / drug effects Pentobarbital / pharmacology Rabbits Verapamil / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Calcium Channel Blockers; 52-53-9/Verapamil; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Growth of injected melanoma cells is suppressed by whole body exposure to specific spatial-temporal ...
Next Document: Lack of evidence for low-LET radiation induced bystander response in normal human fibroblasts and co...