| Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells. | |
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MedLine Citation:
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PMID: 20459219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering. |
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Authors:
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YongKeun Park; Monica Diez-Silva; Dan Fu; Gabriel Popescu; Wonshik Choi; Ishan Barman; Subra Suresh; Michael S Feld |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical optics Volume: 15 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-05-12 Completed Date: 2010-09-13 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 020506 Citation Subset: IM |
Affiliation:
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Massachusetts Institute of Technology, G. R. Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. ykpark@mit.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Erythrocytes
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parasitology*,
pathology* Humans Light Nephelometry and Turbidimetry / methods* Plasmodium falciparum / pathogenicity, physiology* Reference Values Scattering, Radiation |
| Grant Support | |
ID/Acronym/Agency:
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1R01HL094270-01A1/HL/NHLBI NIH HHS; P41-RR02594-18/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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