| Static and dynamic autonomic response with increasing nausea perception. | |
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MedLine Citation:
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PMID: 21485400 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Nausea is a commonly occurring symptom typified by epigastric discomfort with urge to vomit. The relationship between autonomic nervous system (ANS) outflow and increasing nausea perception is not fully understood. METHODS: Our study employed a nauseogenic visual stimulus (horizontally translating stripes) while 17 female subjects freely rated transitions in nausea level and autonomic outflow was measured (heart rate, HR; heart rate variability, HRV; skin conductance response, SCR; respiratory rate). We also adopted a recent approach to continuous high-frequency (HF) HRV estimation to evaluate dynamic cardiovagal modulation. RESULTS: HR increased from baseline for all increasing nausea transitions, especially transition to strong nausea (15.0 +/- 11.4 bpm), but decreased (-6.6 +/- 4.6 bpm) once the visual stimulus ceased. SCR also increased for all increasing nausea transitions, especially transition to strong nausea (1.76 +/- 1.68 microS), but continued to increase (0.52 +/- 0.65 microS) once visual stimulation ceased. LF/HF HRV increased following transition to moderate (1.54 +/- 2.11 a.u.) and strong (2.57 +/- 3.49 a.u.) nausea, suggesting a sympathetic shift in sympathovagal balance. However, dynamic HF HRV suggested that bursts of cardiovagal modulation precede transitions to higher nausea, perhaps influencing subjects to rate higher levels of nausea. No significant change in respiration rate was found. CONCLUSIONS: Our results suggest that increasing nausea perception is associated with both increased sympathetic and decreased parasympathetic ANS modulation. These findings corroborate past ANS studies of nausea, applying perception-linked analyses and dynamic estimation of cardiovagal modulation in response to nausea. |
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Authors:
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Lauren T LaCount; Riccardo Barbieri; Kyungmo Park; Jieun Kim; Emery N Brown; Braden Kuo; Vitaly Napadow |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Aviation, space, and environmental medicine Volume: 82 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-12 Completed Date: 2011-05-12 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 424-33 Citation Subset: IM; S |
Affiliation:
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Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth St., #2301, Charlestown, MA 02129, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Autonomic Nervous System / physiology* Female Galvanic Skin Response Heart Rate Humans Nausea / physiopathology* Parasympathetic Nervous System / physiology* Respiratory Rate Space Flight Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1 UL1 RR025758-01/RR/NCRR NIH HHS; F05-AT003770/AT/NCCAM NIH HHS; K01 AT002166-05/AT/NCCAM NIH HHS; K23-DK069614/DK/NIDDK NIH HHS; P01-AT002048/AT/NCCAM NIH HHS; P41RR14075/RR/NCRR NIH HHS; R01 AT004714-03/AT/NCCAM NIH HHS; R01 HL084502-05/HL/NHLBI NIH HHS; R01-AT004714/AT/NCCAM NIH HHS; R01-HL084502/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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